Identifying Basal Ligase-Substrate Interactions for Molecular Glue Discovery
Time: 8:30 am
day: Conference Day 2
Details:
• Introducing AlphaSeq, enabling large-scale mapping of basal protein-protein interactions between therapeutically relevant substrates and a diverse repertoire of ligases and chaperones, providing a rich starting dataset for molecular glue discovery
• Sharing how machine learning models can integrate aggregate PPI data to predict neosubstrates and can leverage mutation analysis and structural insights to strengthen binding interfaces and uncover new therapeutic opportunities
• Showing how potentially gluable weak basal interactions can be leveraged for small molecule screening, using the AlphaSeq platform or complementary hit identification approaches