Giovanni Spagnolli

Company: Sibylla Biotech srl

Job title: Chief Technology Officer

Seminars:

Developing Optimized Folding Interfering Degraders Targeting Cyclin D1 11:10 am

• Providing an overview of folding interference as a new modality to induce the degradation of a target protein • Demonstrating that folding interfering degraders (FIDs) can be optimized to achieve high potency and desirable ADME properties • Showing in vitro and in vivo characterization of FIDs acting on Cyclin D1Read more

day: Conference Day 2

Panel Discussion: Moving from Phenotypic Screening to Target Based Discovery 8:50 am

• Overview of panellist’s platform technologies to identify glues and degraders including scientific or technical hurdles platforms address • How can we combat the diversity in compounds when rationally designing novel candidates? • What features define a protein as ligandable within a target space? • How can we provide systematic and scalable screening panels; the…Read more

day: Conference Day 2