Yue Xiong

Company: Cullgen Inc.

Job title: Chief Scientific Officer

Seminars:

Discovery of Novel E3 Ligands for Targeted Protein Degradation 2:00 pm

• Discussing how cullin-RING E3 ligases (CRLs) are better suited for developing novel E3 ligands due to their multi-subunit assembly mechanism and intrinsic structural flexibility • What factors to consider for the selection of E3 ligases for developing E3 ligands? • Updating on discovery of novel E3 ligands at CullgenRead more

day: Conference Day 1

Panel Discussion: Where do DACs Fit in? Discussing the Decision to Think about Degraders as Payloads 2:20 pm

• What is it about small molecule degraders that lend themselves to making good payloads? • Sharing parameters that allow a degrader protein to be distinct from a toxic payload • What are some good targets for DACs? • Collaboration potential between antibody engineering and protein degradation companiesRead more

day: Conference Day 2