Randolph Lopez

Company: A-Alpha Bio Inc.

Job title: Co-founder & Chief Technology Officer

Seminars:

Identifying Basal Ligase-Substrate Interactions for Molecular Glue Discovery 8:30 am

• Introducing AlphaSeq, enabling large-scale mapping of basal protein-protein interactions between therapeutically relevant substrates and a diverse repertoire of ligases and chaperones, providing a rich starting dataset for molecular glue discovery • Sharing how machine learning models can integrate aggregate PPI data to predict neosubstrates and can leverage mutation analysis and structural insights to strengthen…Read more

day: Conference Day 2

Panel Discussion: Moving from Phenotypic Screening to Target Based Discovery 8:50 am

• Overview of panellist’s platform technologies to identify glues and degraders including scientific or technical hurdles platforms address • How can we combat the diversity in compounds when rationally designing novel candidates? • What features define a protein as ligandable within a target space? • How can we provide systematic and scalable screening panels; the…Read more

day: Conference Day 2